[3pt14159]

Presuming we're not in a simulation then I think it is unlikely that we're alone in the Milky Way.

There are too many stars and too many close enough galaxies that could contain life. If they've been spacefaring for even ten thousand years longer than us then they're almost certainly able to monitor us without our ability to detect it.

But if we're doomed to a great filter in the near future, like nuclear war, then it still doesn't mean we're alone. It just means that out there in the sky there are others kinda like us. Searching for meaning before hitting a technological explosion of one kind or another that wipes us out. But just because we don't have contact doesn't mean we're alone, even if we're only present in each others respective imaginations.