[xiphias2]

In my opinion the most important medical advance that happened was reversing methylation based age indicator for the first time in a human. It's a bit sad to not see something so important on this list.

[rococode]

For anyone curious, I believe this is the relevant paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138/

And a blog post about it: https://www.activemotif.com/blog-reversing-epigenetic-age

[ekianjo]

N=10 though... And needs to be reproduced ideally.