[hexxiiiz]

Geez. Unless there is there is some mechanism posited, it is hard not to roll ones eyes at studies like this. How would, hypothetically, the THC, and other cannabinoids in canibus cause this to happen given their effect on the endocrine system? The sample size looks large at over 3k until you see that the regular use group is 47 and the infrequent use group is just past 100. So we have 20x non-users to users based on self-reporting. Is this solid statistics at the least? It could be, but it is a bit misleading. Are the correlations stated after removing confounds? It reads like that is not necessarily the case. Either way, frankly, correlations with no posited mechanism are tremendously unconvincing unless there is way more evidence.

[meowface]

I'm also quite skeptical, but if this actually is accurate, I don't think the potential for a mechanism of action is necessarily that far-fetched. My heart rate absolutely increases to some degree for an extended period of time when I consume sativa cannabis, for example, and I don't think this is uncommon. Changes in heart rate could potentially alter aspects of the heart, over a sufficient length of time.

Even if that weren't the case, cannabis contains lots of psychoactive compounds which aren't fully understood, and even for the ones we do seem to understand, the brain and body are incredibly complex and chaotic systems and could possibly exhibit unexpected effects when exposed to them.