Doesn't the point still stand, though, that you can't use historical usage to prove safety currently (given the change in how we eat food and how long we live)?
Safety is a spectrum really. To give a very binary example we are certain that eating rotten poisonous shark (https://en.wikipedia.org/wiki/H%C3%A1karl) won't kill you because of historical record in spite of eating rotten fish and eating toxic fish separately both being known lethal things.
It doesn't tell us if it is optimal health wise to do such a thing.
It doesn't tell us if it is optimal health wise to do such a thing.