A number of managed providers have multiple DCs within a region as well as DCs in multiple geographic locations.
Also, many have been in operation since before AWS was a thing, and some are larger. So I can't imagine what AWS knows about running a datacenter that others don't.
Now maybe in theory if you can build something to be fully one with the cloud, considering all edge cases, and limiting yourself to only cloud-zen tools (or building your own, or doing vendor lock in). In theory, with enough money, I guess the cloud lets you maybe achieve higher reliability.
The fundamentals of EC2 (lack of dual NICs, dual power supplies and BBU RAID + virtualization and general complexity) means that a single instance is way less reliable (let alone, much worse value) than a single dedicated box. The complexity you need to throw on top of that building block (in the shape of lock-in, compromise, money, latency, application complexity or a combination of these) is pretty significant.
I'm not sure what the point is, actually. The variety of things that can go wrong with them is astonishing. For one thing, among many others, BMC cards will power-cap the max clock speed of CPUs when a machine is running on only one PSU, which can cause a degradation that's worse than if the machine had just halted. There are a zillion other edge cases like that.
Managed service (like S3) is different than managed infrastructure. EC2 VMs only run in a single zone too and require cost and complexity for more redundancy.
Building out your application across multiple regions in AWS is not much different than using multiple DCs from a managed host. The clouds provide live migration, spot instances, and fast global VPC networks that can make it much easier, but you also pay the premium for it.
Also, many have been in operation since before AWS was a thing, and some are larger. So I can't imagine what AWS knows about running a datacenter that others don't.
Now maybe in theory if you can build something to be fully one with the cloud, considering all edge cases, and limiting yourself to only cloud-zen tools (or building your own, or doing vendor lock in). In theory, with enough money, I guess the cloud lets you maybe achieve higher reliability.
The fundamentals of EC2 (lack of dual NICs, dual power supplies and BBU RAID + virtualization and general complexity) means that a single instance is way less reliable (let alone, much worse value) than a single dedicated box. The complexity you need to throw on top of that building block (in the shape of lock-in, compromise, money, latency, application complexity or a combination of these) is pretty significant.