[heavyset_go]

DAT inhibitors, DA releasers and agonists are effective antidepressants in that they reduce the symptoms of depression. Drugs like Zoloft are DAT inhibitors as well as acting as SSRIs, Wellbutrin is a NET and DAT inhibitor, and MAOIs inhibit the breakdown of serotonin, DA and norepinephrine. Newer antipsychotic medications that are indicated for use as adjunct therapy for depression also have binding action at certain DA receptor sites.

The problem with dopaminergics is that they tend to be addictive, and build tolerance. Both Zoloft and Wellbutrin only inhibit a certain percentage of DAT in areas of the brain related to reward, so they aren't exactly abusable, while something like methylphenidate (which is a potent NET and DAT inhibitor) is.