[mysticlabs]

Biofilms and persister cells are the problem with chronic Lyme disease.

https://rawlsmd.com/health-articles/understanding-biofilm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287027/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521364/

It's pretty simple, if the disease is able to enter the form where it starts producing biofilms it can use them to evade antibiotics. A patient then must explore treatments to break up biofilms, and eradicate whatever infections or co-infections are present within them. There's medications that do this and more functional methods such as hyperbaric oxygen chambers.

The people who have symptoms after antibiotic treatment and the people who relapse after antibiotic treatment still likely contain Lyme disease biofilms and persister cells which are capable of causing a full relapse given enough time and the right conditions.

Those who receive early treatment and success with a single round of antibiotics are the lucky ones, and not the standard patient experience.

Even people who have been bitten by a tick, immediately started antibiotics, and caught it immediately can still get chronic Lyme disease, especially if their initial round of antibiotics was for too short a duration.

There is a lot of shit on the Internet, and what's happening to the people who have Lyme disease is an absolute travesty and crime against humanity due to our corrupt and failing medical system. The actually science and research on this is clear though: biofilms exist, Lyme disease can become chronic due to biofilms and persister cells which can evade antibiotics.

Everyone talks about how theres super bugs and infections that evade antibiotics, well Lyme disease is literally a super bug that evades antibiotics and is probably one of the most successful super bugs of our lifetimes and yet people try to deny its capabilities despite countless medical research studies proving otherwise. It's baffling really.

[cpascal]

To add: there’s also a cystic form of Borrelia burgdorferi.

The bacteria is a spirochete, similar to the bacteria responsible for Syphilis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564911/

https://en.m.wikipedia.org/wiki/Borrelia_burgdorferi

[100ideas]

Are there phage therapy options for persistant lyme disease? Lyme disease is caused by the pathogen Borrelia burgdorferi. A quick pubmed search ([1],[2]) turned up two papers describing phage that interact with Borrelia.

Neither discussed their suitability for phage therapy. The most recent investigated phages as a potential mechanism for horizontal gene transfer b/w Borrelia burgdorferi: https://www.ncbi.nlm.nih.gov/pubmed/27811049

More searching led me to a page titled "Chronic Lime Disease" at the "Phage Therapy Center": https://www.phagetherapycenter.com/pii/PatientServlet?comman...

They seem to have developed phages for clinical treatment of chronic infections (perhaps biofilm mediated) of typical pathogens, and suggest that patients suffering from chronic lyme disease may actually be testing false-positive for Borrelia, and if so, may actually be suffering from chronic biofilm-mediated infection of a more common pathogen. In their words:

>>>> quote <<<<

Sometimes patients who have a legitimate, or otherwise, diagnosis of Chronic Lyme Disease, fibromyalgia or chronic fatigue are actually suffering from a toxin overload that is produced by a particular strain of bacteria. By clearing the treatable bacterial infections and utilizing various techniques to help reduce the toxin loads, there can be much improvement in the patient's overall condition.

Patients who have or who have had Lyme and Lyme co-infections may have serious damage to their immune systems, making them more susceptible to infection. Chronic infections are biofilms, they are colonies of a number of bacteria that together form colonies in various parts of the body - the sinuses, urinary tract, prostate and elsewhere that are inherently more resistant to antibiotics. While in-vitro lab tests may show sensitivity to various antibacterials, such infections typically do not respond to antibiotics. Dr. Tim Lu (MIT), a professor at MIT, explains why biofilms are antibiotic resistant, and why bacteriophage therapy can be effective:

"A classic example of a patient who had a Western Blot test that detected antibodies for Borrelia bergdorferi: Laura Roberts nearly died from her "non-Lyme co-infection", due to a deadly strain of MRSA which was detected by the lab. There are other similar cases." - Dr. Tim Lu - Biofilms and Phage Therapy

To reiterate, if your infection is a biofilm containing Borrelia or any of the Lyme co-infections, phage therapy from our clinic is NOT going to help you. If the infection is caused by one of the treatable genuses (Staphylococcus spp., Streptococcus spp., Enterococcus spp., E. coli, Proteus spp., Pseudomonas aeruginosa, Salmonella spp., Shigella spp., Clostridium difficile (C.Diff), Klebsiella spp., Morganella spp. and several others) there is a good chance we can - but NO GUARANTEE. You will need to test for the presence of these treatable pathogens and even if they are cleared, sometimes symptoms will persist.

>>>>> endquote <<<<<

[1] https://www.ncbi.nlm.nih.gov/pubmed/?term=%22Borrelia%22%5BM...

[2] https://www.ncbi.nlm.nih.gov/pubmed?term=%22Borrelia%2Fvirol...