[michalxnet]

In UK there was just recently published Guidelines for [1] Safe prescribing of fluoroquinolones.

'Do not use fluoroquinolones in patients with known aortic aneurysm, aortic dissection or history of serious side effects related to quinolone treatment (including tendon disease/disorder) unless there are no other treatment options available'

'Patients should be counselled to discontinue fluoroquinolone treatment and seek urgent medical attention at the first sign of:

- Tendon pain or inflammation (particularly in shoulder or ankle)

- Symptoms of neuropathy such as pain, burning, pins & needles, tingling, numbness or weakness

- Sudden-onset of severe and constant abdominal, chest or back pain

1. https://www.ncl-mon.nhs.uk/wp-content/uploads/Guidelines/5_F...

[Engineering-MD]

As far as I am aware, the association with aortic aneurysm is weak ( I think a relative risk of 2) from an associate only study (ie no causation proven). So take these with a pinch of salt, especially for those with a penicillin allergy as covering some bugs without penicillins or flouroquinolones can be tricky.

[dmead]

So basically it fucks with your connective tissue?

[dfsegoat]

> The histopathologic findings [of the tendons] include degenerative lesions, fissures, interstitial edema without cellular infiltration, necrosis and neovascularization [1]

Basically it dissolves, and the achilles tendon is the most common rupture, at least with cipro.

1. https://www.ncbi.nlm.nih.gov/pubmed/22035890