If it is true it would buy ad servers greater obfuscation since blockers were relying on CNAME metadata to differentiate between safe and unsafe targets. If more reverse lookup and secondary metadata and vhost dereferencing is required it will complicate performant ad stripping at a minimum.
[0] https://discourse.pi-hole.net/t/apply-pi-hole-blocking-to-cn...
[1] https://github.com/uBlockOrigin/uBlock-issues/issues/780#iss...