Yes. Have had the fun experience of being specifically de-platformed from Stripe because someone at Wells Fargo objected to what we were selling, despite having received Stripe's approval. (This was after several million dollars had run through Stripe, so it obviously caught someone's attention.) Ridiculous, the idea that Wells fucking Fargo is some sort of paragon of virtue.
Eh it's kind of relevant. I worked at a high end tobacco sales company and we were limited to a few payment providers due to selling tobacco online. This amounted to using a very second tier provider. Also PayPal would flag anything with the words Cuba in it. So many cigars use the word Cuba, and we didn't sell those. Annoying at best, but at worse we had more frequent downtimes because our payment gateway wasn't close to reliable.