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by amphitoky 2417 days ago
as others have said, genetic therapies for these kinds of transmissible cancers are not so effective since the cells have already acquired the cancer phenotype. The usual regulatory mechanisms which prevent unchecked proliferation occur in each individual cell, and have already been circumvented by the time cells become cancerous.

I thought I would add that what makes the tasmanian case interesting is that though the body is generally pretty good about detecting and removing foreign cells (including viruses and bacteria), somehow these contagious cancers elude this detection and are allowed to proliferate [1]. It is likely that if the tasmanian devil's immune system were able to detect the intruder cancer cells as coming from another individual, it would eradicate them with ruthless efficiency. Why these cells are able to skirt the host immune system though is a different question.

[1] https://www.ncbi.nlm.nih.gov/pubmed/28695294