[saagarjha]

In general, no, as message sends are observable and swizzlable so they they must go through the bare minimum of objc_msgSend just to make sure that they can be called from the cache. The only exception to this that I know is the retain/release methods, which are rarely overridden and called extremely often, so they have code that doesn't go through the message sending machinery unless necessary (in the case of a custom implementation). And of course, pure Swift calls don’t use the Objective-C runtime at all so they can be optimized as usual.