Obviously, misgendering someone is not likely to be the thing that triggers such an act. But it is part of a pattern of bullying and general disregard that transgendered people face every single day.
Well, that, and there's an orders-of-magnitude difference in homicides between trans and cis people. (And, of course, it's worst for young, black women). Being openly labelled as transgender significantly increases your risk of being assaulted.
That's why misgendering is so insidious - it's stochastic terrorism. The person doing the misgendering can claim that they never meant any violence, but they're still increasing the chance of violence.
https://www.washingtonpost.com/news/morning-mix/wp/2018/09/1...
Obviously, misgendering someone is not likely to be the thing that triggers such an act. But it is part of a pattern of bullying and general disregard that transgendered people face every single day.