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There have been numerous studies on this, and the results are basically always: people don’t think that it’s faster to stick with the keyboard, but it is. Yes, even for people who are very familiar with the task, the keyboards, and the mice.

There are some interactions where switching to the mouse and back is faster; things like drawing and navigation through irregular shapes (I.e. “not grids or lists”).

Whether that difference is important to you or not is far more about your specific circumstances than anything else. Comfort is important also.