Perhaps I could see some toy ransomware bootkit demanding the user to pay up or face using your computer with comic neue or comic sans as the default unchangeable font.
Pairs nicely with Fantasque Sans Mono (though if there was a more Comic Sans/Neue-like typeface, I'd set that as my terminal/editor font in a heartbeat).
For the uninitiated:
http://www.comicneue.com/
As far as Comic Sans-like fonts go it's quite nice