[cwkoss]

I wonder if grapefruit + reduced dosage could be as effective for primary effects, but reduce side effects for some drugs.

Would be interesting to find some research in this area: most of what I can find warns of increased side effects from maintaining constant dosage.

Interesting related info: "Seville oranges, (often used in marmalades), limes and pomelos also produce this interaction. Varieties of sweet orange, such as navel or valencia, do not contain furanocoumarins and do not produce this interaction."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/

[emmelaich]

I've heard it's best to avoid or reduce citrus intake while taking drugs.

I don't know why, but this could be why.