[logfromblammo]

Reactor fuels or RTG cores are a bit more dangerous than ore.

A properly designed reactor requires the fuel to be in the core to sustain a chain reaction, and neutron activation of other elements in the reactor does not occur until the reaction has started. Thus, a rocket explosion would not cause a criticality event. The worst that would happen would be dispersion of nuclear fuel to a place where someone might handle it without its transport-safety shielding. Which still wouldn't be that bad.