[rjf72]

All evolution ultimately is, is the result of factors favorable to reproduction staying the gene pool, since those with them quite tautologically tend to reproduce more, while factors unfavorable to reproduction get culled vice versa.

For a recent example of evolution on a practically real time scale see this [1]. Scientists released millions of genetically engineered mosquitoes into the wild. The genetically engineered mosquitoes were all male and engineered to produce infertile offspring. However, rare abnormalities allowed some mosquitoes to end up producing fertile offspring. The entire target population (in the wild) then began to adopt these characteristics and ended up rebounding from near extermination to near pre-release numbers.

That is evolution in fast forward due to a rapid reproduction rate, but even on a generational level this would have been an extremely rapid evolutionary adaptation.

And the same applies to humans. A seemingly ever larger number of things have major genetic factors -- alcoholism being one we've known about for quite some time. Alcoholics are less likely to live to successfully reproduce, and even when producing may produce defective offspring as a result of their alcoholism. So it creates an evolutionary imperative against susceptibility to alcoholism.

[1] - https://www.nature.com/articles/s41598-019-49660-6