[loeg]

Sorry, that wasn't really the idea I was trying to express at all. The two points are "using opioids as prescribed by Dr" => "using the same opioids in a way that was not prescribed."

I know off-label is specific industry jargon and it doesn't mean the way I tried to use it; sorry for the confusion.

Totally agree that chronic pain is a hard problem and tolerance effects make opioids a non-ideal long term solution. That said, I am neither a Doctor nor a researcher in the pharma industry so I don't have a lot of helpful suggestions for anything better than opioids today.