The Angular project has a package for translating TS -> Closure, which appears to be used at Google in some capacity. https://github.com/angular/tsickle
It would be really cool to see the user-friendly version (though that might lead to a rabbit hole on the Closure side, too). The Closure compiler remains awesome, just difficult to make use of successfully.
It's a bit difficult to hook up though, and we haven't had the cycles to make the open source version user friendly, I'm afraid :-(