[nikolay]

I lot of people look at just one part of biology and totally ignore all the basics only focusing on aging reversal and living forever. First, autophagy is nice to have it done from time to time, not constantly. If you constantly activate it, then your cells will reach the Hayflick limit. So, you need to boost your telomerase... but then you can more easily get cancer.

The best strategy for me is lower metabolism, undereat, and reduce cellular damage and senescence. In some cases, senescence can be reversed (a friend of mine is doing a beta cell research at UCLA, and they've done that to some extent.) Of course, there are other strategies, involving stem cells, but I'm not familiar with that part - maybe they can compensate the negative effects of autophagy.