Not sure what you consider it "this sort of thing", but native speakers of Australian aboriginal language Guugu Yimithirr have nearly superhuman sense of direction. They can automatically tell where is north, south, east, and west.
I believe they don't actually use left and right, but use the cardinal direction instead. So it's something they need to be constantly aware of. Ie: their kids song would go "Put your south hand in, put your south hand out.."
Indonesia’s Bajau people, who for generations have spent the majority of their days diving and hunting underwater, have genetic adaptations that include spleens that are around 50% larger than those of their land-based neighbors. https://www.sciencemag.org/news/2018/04/indonesian-divers-ha...
You'd imagine this would be basically a death sentence, but she's made it to old age. She also has a lack of adrenaline response, so is basically super chill. Hard to argue this is a beneficial mutation, but perhaps as technology evolves we could self-monitor artifically and not have to worry about these deeply unpleasant physiological warning bells?
http://pages.ucsd.edu/~jhaviland/Publications/ETHOSw.Diags.p...