I am quite familiar with Spec. In my few years of professional Clojure experience, working with people who write Clojure every day, and enjoy it, and advocate using things like Spec, I have never actually seen anyone do it successfully in practice.
I understand the idealist world view is seductive — we'll be discipined, we'll write the tests, we'll make good use of Spec, etc etc.
In reality, I have never seen this happen. Humans are lazy and undisciplined, so that's what I optimise for.
We use spec a lot, using orchestra’s defn-spec combined with expound for improved error reporting.
It’s not a type system, but it’s very concise and easy to add validations to important functions. This removes the “lazy and undisciplined” part of the equation.