[beagle3]

Clinical researchers working for non-profits / universities do, occasionally. I suspect it has become popular recently not because lives are at stake, but because it lets you publish something meaningful without having to run complex, error prone and lengthy experiments.

Regardless of the true reason, these are never carried out before a new drug or treatment is approved (because there is usually one or two studies supporting said treatment, both positive).

And if you have pointers to techniques developed for/by EBM practitioners, I would be grateful. Being a bayesian guy myself and having spent some time reading Lancet, NEMJ and BMJ papers, I'm so far unimpressed, to say the least.