| HN Mirror

Not that you and I disagree, but some important additional details on the matter:

> Actually agree with grandparent about the benefits of psilocybin, but you probably shouldn't listen to a stranger on the internet about that anyway.

You certainly shouldn't base your opinion on one comment on the internet. What you should do they is consider it a possibility and do your own research, at which time you will discover there is significant discussion on the internet among both layman and professionals about not just the observed benefits (sometimes bordering on the profoundly amazing [1]), but also increasing detailed, science-based theories about the underlying physiological and neurological causes for the observed successes.

You will also realize the ratio of successful outcomes to unsuccessful (no result or harmful) are heavily skewed towards successful stories. Is this ratio driven by a bunch of drug-addled delusional lunatics, or might there be something interesting going on here?

[1] https://www.newyorker.com/magazine/2015/02/09/trip-treatment

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As I chatted with Tony Bossis and Stephen Ross in the treatment room at N.Y.U., their excitement about the results was evident. According to Ross, cancer patients receiving just a single dose of psilocybin experienced immediate and dramatic reductions in anxiety and depression, improvements that were sustained for at least six months. The data are still being analyzed and have not yet been submitted to a journal for peer review, but the researchers expect to publish later this year.

“I thought the first ten or twenty people were plants—that they must be faking it,” Ross told me. “They were saying things like ‘I understand love is the most powerful force on the planet,’ or ‘I had an encounter with my cancer, this black cloud of smoke.’ People who had been palpably scared of death—they lost their fear. The fact that a drug given once can have such an effect for so long is an unprecedented finding. We have never had anything like it in the psychiatric field.”

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"But this can't possibly be true", one might semi-reasonably propose, "because if it was we would surely know about it!"

Incorrect. That is an logical/epistemic error, something that is at the foundation of a large portion of any common disagreement in society, from politics to finance to personal relationships.

As the saying goes: "It Ain’t What You Don’t Know That Gets You Into Trouble. It’s What You Know for Sure That Just Ain’t So"."

One reason "because if it was we would surely know about it" should not be taken for granted is in the same article:

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“I felt a little like an archeologist unearthing a completely buried body of knowledge,” he said. Beginning in the nineteen-fifties, psychedelics had been used to treat a wide variety of conditions, including alcoholism and end-of-life anxiety. The American Psychiatric Association held meetings centered on LSD. “Some of the best minds in psychiatry had seriously studied these compounds in therapeutic models, with government funding,” Ross said.

Between 1953 and 1973, the federal government spent four million dollars to fund a hundred and sixteen studies of LSD, involving more than seventeen hundred subjects. (These figures don’t include classified research.) Through the mid-nineteen-sixties, psilocybin and LSD were legal and remarkably easy to obtain. Sandoz, the Swiss chemical company where, in 1938, Albert Hofmann first synthesized LSD, gave away large quantities of Delysid—LSD—to any researcher who requested it, in the hope that someone would discover a marketable application. Psychedelics were tested on alcoholics, people struggling with obsessive-compulsive disorder, depressives, autistic children, schizophrenics, terminal cancer patients, and convicts, as well as on perfectly healthy artists and scientists (to study creativity) and divinity students (to study spirituality). The results reported were frequently positive. But many of the studies were, by modern standards, poorly designed and seldom well controlled, if at all. When there were controls, it was difficult to blind the researchers—that is, hide from them which volunteers had taken the actual drug. (This remains a problem.)

By the mid-nineteen-sixties, LSD had escaped from the laboratory and swept through the counterculture. In 1970, Richard Nixon signed the Controlled Substances Act and put most psychedelics on Schedule 1, prohibiting their use for any purpose. Research soon came to a halt, and what had been learned was all but erased from the field of psychiatry. “By the time I got to medical school, no one even talked about it,” Ross said.

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