[marmaduke]

> I think it's generally acceptable that one does not need to do molecular dynamics to recreate membrane voltages

everyone draws the line somewhere, this is yours. Even we take this statement to be true, you still have metabolic networks changing transmitter concentrations, dendritic arbors evolving in entirely unidentifiable ways, etc. The goal of modeling is not to say that every detail is there, but ones relevant to account for specific feature of data.

[buboard]

While there is more detail that can be simualted, there is a vast very successful literature using compartmental models. Markram's work was the simulation of a cortical column with compartmental models anyway.