Hacker News new | ask | show | jobs
by Gatsky 2529 days ago
There are several inaccuracies in your comment. Infusion reactions to paclitaxel are rare and not serious. Most of the toxicity arises from cumulative nerve damage with chronic use.

There is also no evidence it promotes cancer recurrence.

2 comments

You better believe the infusion reactions can be serious, despite what any medical literature may be leading you to believe. My father went into anaphylaxis within minutes of his Taxol infusion. My family was kicked out of the treatment room while six medical workers stabilized him over the course of an afternoon.
My reaction wasn't as severe but I had a taxol based reaction as well. It's a barrel of fun, luckily mine was treatable with Benadryl. I don't envy you or your father.
I appreciate any & all correction—I’m still learning myself.

I say toxic relative to the Benzimidazole family of medication, and though Paclitaxel’s worst side effects, like the neuropathy you mention, come cumulatively with chronic use, it’s more common side effects are still numerous, including a few serious ones, from sources I find.

And “promotes cancer recurrence” was a poor choice of term on my part. What I mean here is the time between doses is wide enough to permit recurrence in some cases.