I don’t think it’s happened (yet) although some of the earlier outages when AWS was younger were pretty far reaching. I think all of S3 has gone down a time or two.
Some APIs were impacted, because they are global by nature (e.g create-bucket). But S3 was working fine in all other regions, for existing buckets.
However, many websites were affected, because they didn't use any of the existing S3 features that allow for regional redundancy, simply because S3 had been so reliable they didn't know/think they needed to have critical assets in a bucket in a 2nd region that they could fail over to.
Admittedly, even the AWS status page was impacted, because it also relied on S3 in us-east-1.
S3 has done a lot of work to improve matters since, and mechanisms have been put in place to ensure that all AWS services don't have inter-region dependencies for "static" operation.
However, it is still incorrect to claim that it was all of S3. Many customers who use S3 only in other regions were totally unaffected.