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by less_penguiny 2556 days ago
FWIW Gwern has done some careful self-experiments on magnesium supplementation, finding it wasn't all rosy: https://www.gwern.net/nootropics/Magnesium
2 comments

Magnesium truly does wonders for my sleep but every single person I’ve recommended it to has not had similar results. Like many things I’m sure there’s a significant difference depending on your biochemistry.
> Like many things I’m sure there’s a significant difference depending on your biochemistry.

...and placebo effect.

Practically speaking, it doesn't matter how much the effects are mediated by the placebo response; whatever helps you sleep at night.
ESPECIALLY for something that's so delicate as sleep.
What were your initial sleep issues and how does MG help? Also, do you take it right before bed or is it something that just builds up in increasing effectiveness after taking it daily for weeks / months?
It's a long read with a lot of data and can be hard to make sense of. Here is the TLDR:

Conclusion

The interpretation which seems to best resolve everything I know about magnesium with the data from my experiment is that magnesium supplementation does indeed help me a large amount, but I was taking way too much.

The couple paragraphs above this citation are also worth reading, in particular:

I find this very troubling. The magnesium supplementation was harmful enough to do a lot of cumulative damage over the months involved, but not so blatantly harmful enough as to be noticeable without a randomized blind self-experiment or at least systematic data collection—neither of which are common among people who would be supplementing magnesium I would much prefer it if my magnesium overdose had come with visible harm (such as waking up in the middle of the night after a nightmare soaked in sweat), since then I’d know quickly and surely, as would anyone else taking magnesium. But the harm I observed in my data? For all I know, that could be affecting every user of magnesium supplements! How would we know otherwise?