[krilly]

People who take it every weekend will get a kind of permanent tolerance where they'll never feel the magic again no matter how long they wait. And apparently permanently affect their ability to feel happiness.

This is common knowledge in the drugs community and harm reduction sources frequently quote the 3 month thing, although I'm not sure where it originally came from.

[throwaway0524]

This doesn't match my personal experience at all. I'm in my 40s, husband is in 50s, both took massive amounts of mdma in the 90s and 2000s, way above the guidelines you are describing both in terms of single night usage and frequency, and still do today but much less frequently. Large cohort of friends with similar histories. We seem fine. Husband is about the most naturally happy, well adjusted person you could meet and his consumption of mdma at times was sort of over the top.

Ymmv!

It absolutely does screw with some people's mood for the worse, but definitely not everyone, or even most people. I do think for people predisposed to depression and anxiety, heavy usage can be a bad triggering or worsening factor.

[tempguy9999]

That is an absolute statement without any references. Please don't quote hearsay.

I don't speak for anyone else but it does not match my experience and FWIW I've been taking it once a week for ~4.5 years.

(Explanation; I consider that dose and rate as a definite abuse of it, not sensible use, but the past few years have been just terrible god knows how I would have coped without it. I'm improving now and started cutting down, and looking forward to going out without any drugs, even alcohol).

[TheOperator]

IIRC it comes from only of the early researcherson the subject who I think was ballparking in regards to safety.

Until people come out with some real data I would stick with the cautious approach.