[dannykwells]

Re: resistance - it's not that the tumor is resistant to the immunotherapy, it's that the tumor is resistant to the immune system, and the therapy provided doesn't do the right thing to break down the resistance barrier. There are literally dozens of unique ways a tumor can suppress the immune system. So the challenge for each patient is finding which ones the tumor is using .

There are cases of adaptive resistance to immune-based therapies. These are less common, although they do arise. However, it is still the same kind of game - tumors use the same tricks to hide from an immune response ignited by an immunotherapy as they do from an immune response without immunotherapy.