[SkyMarshal]

/second Nix on OSX. In addition to your reasons, it doesn't depend on the Mac community for growth and support as Homebrew and MacPorts do. Regardless how many OS X users use it, its bread and butter is NixOS and the Linux server community.

[viraptor]

Does nix on osx allow you to manage/upgrade native osx packages?

[patrec]

I thinks so, e.g. `nix-env --install --attr nixpkgs.emacsMacport`. But there isn't a huge selection of native macOS GUI apps.