[RyanGWU82]

It's a lot more favorable when you have few domains and many queries. We have many tens-of-millions of queries per month, on only two domains. This would cut 75% off our DNS hosting.

[haploid]

Same here. This would be a nice little cost saver, except it appears they don't support anycast. As such, it's a nonstarter for us.

[jgreen10]

"The query resolution functionality of Route 53 is based on anycast, which will route the request automatically to the DNS server that is the closest."

http://www.allthingsdistributed.com/2010/12/dns_amazon_route...

[moe]

Just to clarify: All sources I've read claim it is anycast.