[eapartridge]

I've used it for a couple small projects in the context of trying Iodide.

It's pretty good for data science—I can't speak to DOM manipulation that much, I've only done very minimal work with it for that. My two cents: it's bit rough around the edges—the performance is noticeably worse, and for data science, with medium-sized datasets it can freeze a tab for 10-15 seconds. Sometimes you get an odd edge case though where standard Python cannot run perfectly due to some combination of operations.

That said, overall, I'm really excited by where it's going, and I've always been able to work around the limitations.