[temp2903d]

250mg seems exceptionally high (in reference to the OP's response below). The esketamine nasal spray that was just approved contains only 28mg per dose (1-2x/week). I don't know if that's because you need more if you take it sublingually. Snorting/nasal is almost certainly the most efficient/most effective way to take it.

[atomical]

1) The different ROAs have different bioavailability.

2) Ketamine is cheap. Convenience should be prioritized over efficiency.

[throwaway0x69AF]

It's not just about the expense, ketamine can damage liver and kidneys, and reduce iron uptake. Efficiency, in this case, is more about harm reduction than expense

[atomical]

I've read some of the most important papers and books and have never come across this. Please post a source.

Depression is a very serious illness and ketamine is a very safe drug. We need to give people more options.