DoH cuts both ways, so be sure you know what are wishing for.
Yes, it allows you to prevent your ISP manipulating your DNS. Your ISP has no way to know when you are resolving, because it is masked in other HTTPS traffic.
But it also allows the apps to prevent you from manipulating their DNS. You don't know when an app is ignoring the resolver you configured system-wide, because it is masked in its HTTPS traffic.
There is a worrying trend that apps (browsers especially) are ignoring whatever you configured in your system, and are becoming basically a blackbox outside your control with a wide open connectivity to the Internet. No explanation needed, what that means for any privacy left.
Yes, it allows you to prevent your ISP manipulating your DNS. Your ISP has no way to know when you are resolving, because it is masked in other HTTPS traffic.
But it also allows the apps to prevent you from manipulating their DNS. You don't know when an app is ignoring the resolver you configured system-wide, because it is masked in its HTTPS traffic.
There is a worrying trend that apps (browsers especially) are ignoring whatever you configured in your system, and are becoming basically a blackbox outside your control with a wide open connectivity to the Internet. No explanation needed, what that means for any privacy left.