| Iron is known to accumulate with age: https://www.ncbi.nlm.nih.gov/pubmed/23237353
It has even been proposed as the mechanism of caloric restriction: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481398/
Here is some literature review that I just found: https://res.mdpi.com/metals/metals-05-02070/article_deploy/m...
The absence of iron excretion mechanism shouldn't be controversial, here is the wikipedia article: https://en.wikipedia.org/wiki/Human_iron_metabolism#Iron_rec... Both iron and manganese are transported by the same molecules and the nutrients inhibit each other, e.g.:https://www.ncbi.nlm.nih.gov/pubmed/2058577 The need of Mn for MnSOD also shouldn't be controverisal: https://en.wikipedia.org/wiki/SOD2 lanthanum changing the concentration of iron in the brain: https://www.sciencedirect.com/science/article/pii/S037842740... Review of lanthanide effects, cites the higher affinity of certain lanthanides to proteins: http://www.actabp.pl/pdf/4_2000/1107.pdf Lanthanum increaseing the capacity of neural transmission, (together with https://www.cell.com/cell/fulltext/S0092-8674(18)31646-5 https://www.nature.com/articles/d41586-019-00198-7?utm_sourc...: https://www.semanticscholar.org/paper/Acute-functional-neuro... The longevity myths are well known, there are local myths of 100+ year old mountain men, (caucasus + some other range in south asia) and the myths of ancient "golden age" when people didn't age are almost universal, and many of the earliest written sources insist on "implausible" ages of certain people. Surprisingly many religions (virtually all, in fact) agree that people started aging when they previously were not and longevity was the normal state until aging was inflicted on people, only the reasoning why it happened varies. - all the abrahamic religions, a very important part of hinduism mentioned in many texts, the greek religion, sumerian, etc. |