[iguy]

According to Wikipedia, "The German V-weapons (V-1 and V-2) cost the equivalent of around USD $40 billion (2015 dollars), which was 50 percent more than the Manhattan Project". That was super high-tech, blue-sky research, which in the end had almost zero military impact. It was not stopped by Allied bombing. It was done at the expense of more practical things, like tanks and planes, despite serious shortages of some of the ingredients (like fuel).

The Manhattan project indeed had a brain trust working on it, the like of which existed nowhere else on the planet. (Maybe more Hungarian than German, though.) Germany could not have replicated that, but it seems likely to me that the brains they did have would have been plenty.

There could have been some other roadblock of course, like the total lack of some material. But I don't know of one. IIRC the Soviets mined about half their Uranium in E Germany, so that was available.