[Pharmakon]

Nicotine is quite toxic at moderately high doses, ask any farmer who works with nicotinoid pesticides, or any ER attending. Nicotine is a potent neurotoxin, it’s just that typical use from smoking and food falls below the threshold for poisoning your nAChRs receptors. However with vaping, that’s no longer the case, especially when people spill their vaping liquid on clothing or skin.

[jpttsn]

Is tolerance also a factor? My daily average nicotine dose is likely above LD50.

[Pharmakon]

I’m not sure if anyone could give you a clear and complete answer to that for humans. The best data I’m aware of is still pretty limited.

https://www.cdc.gov/niosh/idlh/54115.html