[cma]

Even while GC is delayed Python (CPython at least) will free some stuff through reference counting. Only circularly referenced stuff should stick around until the next GC run. So that can avoid lots of stack temporaries and stuff.

[Doxin]

Theoretically with your code structured right you can disable the cyclical garbage collector outright: It only deals with reference cycles which you can explicitly avoid by using the weakref module.

Not entirely sure how you'd go about writing code like that, but it's possible.