[will_brown]

>Is there a state or federal agency that's ever determined an animal to be a threat to people in an area to the degree that they then tried to wipe it out?

In Florida alone that has happened with pythons in the everglades and lionfish in Florida oceans (at least south Florida).

Edit: and African snails. And in a roundabout way mosquitos, but of the lot are not invasive to Florida.