There exist a great one, which is called Figma. They use electron in combination with WebAssembly to make it fast. I'd say that's a pretty decent choice.
Well, the support is pretty decent in evergreen browsers (and it already was for a while), and in case of electron, you have precise control over your runtime, so it's not really a problem. Also many engines have already done quite substantial optimizations for handling wasm modules in combination with JavaScript. It's all done with backward compatibility in mind, so what works today will continue to do so.