[trhway]

>decellularized pig ECMs

why not 3d print the ECMs? Isn't it just basically collagen with some fibrin/laminin thrown into? Do the decellularized ECMs not have any immunogens left? Definitely isn't an issue with the printed ones.

[claytonius]

Unfortunately even with just collagen we can see an immunogenic response that is annoyingly exacerbated by UV cross-linking of the individual collagen proteins. That's why many of the best manufactured ECMs are cross-linked using a mixture of UV exposure and EDC-NHS. Without photolithography i'm not sure you'd be able to get a resolution high enough to mimic native ECM structures.