I agree 100%. Reading On The Road first is essential, but Big Sur for me was the best example of that sharp, cynical ennui which for whatever reason was exactly what I was looking for during that period of my life when I read as much Kerouac as I could find.
I once tried to trek up Matterhorn Peak in the eastern sierra but it was a rainy day and we felt we had to give up the plan. As a result I permanently have an association of sort of a foggy confused state of affairs staring up at the mountain that I can't even see. Apt perhaps