[willsun]

Yup - this line of reasoning is also expressed by Dr. Hall, in the slide here [1]. To answer your question, the study specifically states: "On average, body weight changed by less than 1 kg during the test phase, with no significant difference by diet group in either the intention-to-treat (P=0.43) or per protocol (P=0.19) analysis."

It is interesting that the study authors highlight the higher energy expenditure as an advantage for weight loss, but do not seem to directly address that they did not observe this advantage during the 20 week study period.

[1] https://twitter.com/YoniFreedhoff/status/1062762047677571079

[gamblor956]

Already commented elsewhere, but the researchers noted that the fed the participants different amounts of food each day as necessary to maintain weight. They were testing metabolic differences associated with the ratio of carbohydrates in the diet.

Studies have already shown that weight loss affects metabolic rates.

[willsun]

Thanks for clarifying - this is an important point and seems to explain why there was no noticeable weight loss.

From the paper: "During the test phase, participants’ energy intake was adjusted periodically to maintain weight loss within 2 kg of the level achieved before randomization."