[willydaemon]

You're likely over-considering the scale of your application if you're worrying about whether or not jQuery is adequate for the job. The biggest sites on the internet often depend on jQuery and its a very proven solution. Either you're designing an over-complicated behemoth if you're worrying about jQuery, or you're worrying about a non-issue.

jQuery is still just fine for large-scale applications. You can organize the code any way you have to. Its just Javascript after all.

If your app gets so large that multiple people are doing Javascript though, what you need to do is work on what is considered the boring stuff like version control policies, build processes (look at stuff like Sprockets (http://getsprockets.org/) for some inspiration for instance.

Other than that, jQuery is likely to be a fantastic choice in virtually any front-end engineering that you do.