[reasonattlm]

Immunity is the standard problem for most vectors for gene therapy. Viral vectors have neutralizing antibodies, liposomes get eaten by macrophages, and so forth. Minimizing this issue to the degree needed for a therapy to work is the subject of a great deal of effort over past decades, and ongoing today. It isn't a solved problem, but there are many incremental approaches that, when combined, can let therapies work well enough given good engineering and good fortune.