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by dr_coffee
2785 days ago
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A friend of mine showed me the chemRxiv paper and I realized that although I do research in protein biochemistry, it never occured to me that techniques other than NMR could be used for structural determination of organic molecules. Its cool to take a look at some of the papers linked to realize that the structures are not at all what you would expect from intro level chemistry courses - an all sp2 hybridized molecule doesn't end up being perfectly planar in the crystal structure, it has a slight curvature to it (https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.2018113... paywall sorry), which is probably super important to know if you are trying to design protein inhibitors for therapeutic use. |
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