[shalabhc]

> The big difference is, you instrument a program, but you do not instrument a system.

We do instrument systems, consider strace or https://zipkin.io/

> A comparison would be a computer system is like a biological ecosystem.

Excellent analogy and one that I really like. What are the 'programs of biology'? One way of decomposing this is 'spacial' - e.g. a cell is a program, a limb or an organ is another larger one etc. But what about the nervous system, circulatory system, etc.? Aren't they useful perspectives but they span different units in the spacial decomposition. Can I view and modify them directly? What about updates - consider attaching another limb vs changing the electrical conductivity of neurons - while preserving some consistency and enforcing constraints.