[zergov]

If you're familiar with Django, just go for it. The documentation is really nice and it is batteries included: admin panel, authentication, permissions and more. All this free stuff will let you focus on your app instead of what is around it.

For the frontend, it depends on your goals. If you need a quick prototype, just use the Django templating engine and ship something quick. If you want to learn, choose a popular frontend framework and stick to it. They are all pretty good. Check their API / ecosystems and pick the one you like :)